Enhanced Leishmania braziliensis Infection Following Pre-Exposure to Sandfly Saliva
نویسندگان
چکیده
منابع مشابه
Enhanced Leishmania braziliensis Infection Following Pre-Exposure to Sandfly Saliva
BACKGROUND Sand fly saliva has an array of pharmacological and immunomodulatory components, and immunity to saliva protects against Leishmania infection. In the present study, we have studied the immune response against Lutzomyia intermedia saliva, the main vector of Leishmania braziliensis in Brazil, and the effects of saliva pre-exposure on L. braziliensis infection employing an intradermal e...
متن کاملA mouse model of Leishmania braziliensis braziliensis infection produced by coinjection with sand fly saliva
To development a reliable murine model of Leishmania braziliensis braziliensis infection, parasites were injected into BALB/c mice in the presence of phlebotomine sand fly salivary gland lysates, which have previously been shown to greatly increase the infectivity of L. major in mice. When injected with salivary gland lysates, L. braziliensis braziliensis produced progressively enlarging cutane...
متن کاملImmunity to Lutzomyia whitmani Saliva Protects against Experimental Leishmania braziliensis Infection
BACKGROUND Previous works showed that immunization with saliva from Lutzomyia intermedia, a vector of Leishmania braziliensis, does not protect against experimental infection. However, L. braziliensis is also transmitted by Lutzomyia whitmani, a sand fly species closely related to Lu. intermedia. Herein we describe the immune response following immunization with Lu. whitmani saliva and the outc...
متن کاملThe immunobiology of Leishmania braziliensis infection
Leishmaniases are a group of diseases caused by protozoa of the genus Leishmania that affect millions of people worldwide. These diseases are caused by distinct Leishmania species, of which L. braziliensis, a New World representative of the Leishmania genus, has been the least studied. Although leishmaniasis caused by L. braziliensis induces a range of clinical manifestations ranging from mild ...
متن کاملExposure to Leishmania braziliensis Triggers Neutrophil Activation and Apoptosis
BACKGROUND Neutrophils are the first line of defense against invading pathogens and are rapidly recruited to the sites of Leishmania inoculation. During Leishmania braziliensis infection, depletion of inflammatory cells significantly increases the parasite load whereas co-inoculation of neutrophils plus L. braziliensis had an opposite effect. Moreover, the co-culture of infected macrophages and...
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ژورنال
عنوان ژورنال: PLoS Neglected Tropical Diseases
سال: 2007
ISSN: 1935-2735
DOI: 10.1371/journal.pntd.0000084